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CPD Activity Details


Pharmacokinetics
Starting on:
Mar 9, 2026
Ending on:
Mar 9, 2026
Moderator(s):
Venue:
KUTRRH
Max Credits:
3 Points

Provider:
Kenyatta University Teaching and Referral Hospital
Claim Points

Pharmacokinetics

Starting on:
Mar 9, 2026
Ending on:
Mar 9, 2026
Venue:
KUTRRH

Description

This training provides an overview of pharmacokinetics and its application in anaesthesia practice. It explores how the body handles administered drugs through the processes of absorption, distribution, metabolism, and excretion (ADME). The session covers fundamental pharmacokinetic principles including membrane transfer, compartment models, volume of distribution, clearance, drug metabolism, elimination kinetics, and practical applications such as steady-state drug concentrations and context-sensitive half-time. The training emphasizes the clinical relevance of pharmacokinetic concepts in predicting drug effects, optimizing dosing, and improving patient safety during anaesthesia and critical care.

Objectives

Define pharmacokinetics and describe its role in predicting drug concentrations and clinical effects over time. Explain the general principles of pharmacokinetics, including membrane transfer, exponential processes, pharmacological compartment models, volume of distribution, and clearance. Describe drug absorption and discuss factors influencing bioavailability, first-pass metabolism, and different routes of drug administration. Discuss drug distribution mechanisms, including tissue perfusion, physiological barriers, compartmental distribution, and factors affecting volume of distribution. Differentiate between Phase I and Phase II metabolism, including the enzymes involved and their clinical significance. Explain the processes of drug excretion, including renal and biliary elimination, and recognize the impact of age and organ dysfunction on drug clearance. Compare first-order and zero-order kinetics and describe their implications for drug dosing, toxicity, and steady-state achievement. Apply pharmacokinetic principles in clinical anaesthesia practice, particularly in establishing steady state, interpreting context-sensitive half-time, and improving predictability of drug dosing and patient recovery.

Presenters

  1. Dr. Abdirauf Dekow


  2. Dr. Peter Kariuki


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